Sermorelin calculator
A GHRH analog historically used in diagnostic testing and now dispensed largely through compounding pharmacies.
Also known as: GRF 1-29, Sermorelin Acetate, Sermorelin acetate
FDA status — not an approved drug Previously FDA-approved as Geref, withdrawn from the US market in 2008 for commercial reasons. It is not currently marketed as an FDA-approved product but does appear on FDA's Category 1 bulk substances list for compounding.
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What Sermorelin is
Sermorelin is a synthetic fragment of growth hormone releasing hormone, consisting of its first 29 amino acids — the shortest portion that retains full activity. It was approved in the United States as Geref and used both to treat pediatric growth hormone deficiency and as a diagnostic test of pituitary function.
Research depth: 4/5 Decades of clinical use and research behind its former FDA approval, including diagnostic and pediatric growth studies. Human trials: Approved-era clinical trials. This measures how much has been studied — counting animal and laboratory work — not whether it works for you.
How Sermorelin works
It binds pituitary GHRH receptors and stimulates natural growth hormone production and release. Because the pituitary remains in charge, the resulting GH pulses follow a more physiologic pattern than injected growth hormone, and negative feedback still applies.
Sermorelin side effects
Commonly reported
- Injection-site redness, swelling, or pain — the most frequently reported effect
- Flushing
- Headache
- Dizziness
- Trouble swallowing or a sensation of restlessness
Serious — seek medical care
- Hypersensitivity reactions
- Effects on glucose metabolism with prolonged use
- Should not be used in anyone with an active malignancy
This list is not exhaustive. Report anything unexpected to the clinician who prescribed it. If you have severe abdominal pain, trouble breathing, or signs of an allergic reaction, seek care the same day. See also our guide to peptide side effects by class.
A worked example
A 5 mg vial reconstituted with 2 mL of bacteriostatic water gives 2.5 mg/mL. A 200 mcg dose is then 0.08 mL — about 8 units on a 100-unit insulin syringe, giving roughly 25 doses per vial before accounting for residual volume left in the vial and syringe.
Prefer paper? Download the printable Sermorelin dosing chart (PDF) — every vial size and water volume in syringe units, with the same review byline as this page. All charts →
Commonly cited dose range
Figures circulating for Sermorelin run from 100 mcg to 500 mcg. Compounded sermorelin is prescribed at clinician discretion. Follow the labeling that comes with your prescription.
Read this as reference information, not instruction. These numbers describe what is commonly discussed, not what is right for any individual. Dose, frequency, and whether to use Sermorelin at all are decisions for a licensed clinician who knows your history.
Common questions
Is sermorelin FDA-approved?
Not currently. The original branded product, Geref, was withdrawn from the US market in 2008 for business reasons rather than safety findings. Sermorelin remains available through compounding pharmacies with a prescription.
How do I reconstitute a 9 mg sermorelin vial?
With 3 mL of bacteriostatic water a 9 mg vial gives 3 mg/mL, so a 300 mcg dose is 0.1 mL — 10 units. Your pharmacy's instructions take precedence over any general calculator.