Lysine-Proline-Valine calculator
The three-amino-acid sequence that makes up KPV, the anti-inflammatory fragment of alpha-MSH. See the KPV entry for the full picture.
Also known as: KPV tripeptide, Lys-Pro-Val
FDA status — not an approved drug Not FDA-approved for any use. This is the KPV tripeptide, a research peptide not reviewed by FDA for safety, effectiveness, or quality.
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What Lysine-Proline-Valine is
Lysine-proline-valine is the full name for the tripeptide abbreviated KPV — the active end of the hormone alpha-MSH. It is studied for anti-inflammatory effects without the pigmentation effects of the parent hormone. Research is largely preclinical, with some early human work in gut inflammation.
Research depth: 2/5 Preclinical anti-inflammatory data with early translational work; no large human trials. Human trials: Early-phase only. This measures how much has been studied — counting animal and laboratory work — not whether it works for you.
How Lysine-Proline-Valine works
It enters cells and is thought to reduce inflammatory signaling by inhibiting NF-kB and related pathways, lowering the production of inflammatory cytokines. Unlike the full alpha-MSH hormone, it does not strongly activate the receptor that drives skin darkening, which is why it is studied separately.
Lysine-Proline-Valine side effects
Commonly reported
- Injection-site reactions
- No systematic human safety data
- Theoretical immune-modulating effects under study
Serious — seek medical care
- Unknown long-term safety in humans
- Immune modulation could matter for people with autoimmune conditions
- Unregulated products carry purity and sterility risks
This list is not exhaustive. Report anything unexpected to the clinician who prescribed it. If you have severe abdominal pain, trouble breathing, or signs of an allergic reaction, seek care the same day. See also our guide to peptide side effects by class.
A worked example
A 10 mg vial reconstituted with 2 mL of bacteriostatic water gives 5 mg/mL. A 500 mcg dose is then 0.1 mL — about 10 units on a 100-unit insulin syringe, giving roughly 20 doses per vial before accounting for residual volume left in the vial and syringe.
Prefer paper? Download the printable Lysine-Proline-Valine dosing chart (PDF) — every vial size and water volume in syringe units, with the same review byline as this page. All charts →
Commonly cited dose range
Figures circulating for Lysine-Proline-Valine run from 250 mcg to 1000 mcg. This is the KPV tripeptide — figures reflect community reference amounts in micrograms. There is no established or approved dose.
Read this as reference information, not instruction. These numbers describe what is commonly discussed, not what is right for any individual. Dose, frequency, and whether to use Lysine-Proline-Valine at all are decisions for a licensed clinician who knows your history.
Common questions
Is lysine-proline-valine the same as KPV?
Yes. KPV is simply the abbreviation for the three amino acids lysine (K), proline (P), and valine (V). They are the same tripeptide, studied for anti-inflammatory effects. See the KPV entry for the full detail.
What is it used for?
As KPV, it is studied for anti-inflammatory effects, particularly in the gut and skin. Human evidence is preliminary.