DSIP calculator
A nonapeptide studied for sleep and stress effects since the 1970s. Evidence for a clear sleep-inducing effect is inconsistent.
Also known as: Delta Sleep-Inducing Peptide
FDA status — not an approved drug Not FDA-approved for any use. DSIP is a research peptide and is not reviewed by FDA for safety, effectiveness, or quality.
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What DSIP is
DSIP (delta sleep-inducing peptide) is a nonapeptide first identified in the 1970s for its apparent association with deep sleep. Despite decades of study, evidence for a consistent sleep-inducing effect in humans is weak and inconsistent, and it has no approved clinical use.
Research depth: 2/5 Decades of study but inconsistent human evidence; no established clinical role. Human trials: Small, equivocal studies. This measures how much has been studied — counting animal and laboratory work — not whether it works for you.
How DSIP works
It was isolated from the blood of animals during deep sleep and was proposed to promote slow-wave sleep and modulate stress hormones. Its exact receptor and mechanism remain poorly defined, and controlled human studies have not confirmed a reliable sleep-promoting effect.
DSIP side effects
Commonly reported
- Injection-site reactions
- No systematic human safety data
- Reported effects are inconsistent
Serious — seek medical care
- Evidence for efficacy is inconsistent despite decades of study
- Mechanism and long-term safety poorly characterized
- Unregulated products carry purity and sterility risks
This list is not exhaustive. Report anything unexpected to the clinician who prescribed it. If you have severe abdominal pain, trouble breathing, or signs of an allergic reaction, seek care the same day. See also our guide to peptide side effects by class.
A worked example
A 5 mg vial reconstituted with 2 mL of bacteriostatic water gives 2.5 mg/mL. A 250 mcg dose is then 0.1 mL — about 10 units on a 100-unit insulin syringe, giving roughly 20 doses per vial before accounting for residual volume left in the vial and syringe.
Prefer paper? Download the printable DSIP dosing chart (PDF) — every vial size and water volume in syringe units, with the same review byline as this page. All charts →
Commonly cited dose range
Figures circulating for DSIP run from 100 mcg to 500 mcg. Community protocols describe doses in the low hundreds of micrograms. Figures shown are reference points. There is no established or approved dose.
Read this as reference information, not instruction. These numbers describe what is commonly discussed, not what is right for any individual. Dose, frequency, and whether to use DSIP at all are decisions for a licensed clinician who knows your history.
Common questions
Does DSIP actually induce sleep?
Despite its name, decades of research have produced inconsistent evidence for a clear sleep-inducing effect in humans. It remains a research peptide without an established clinical role.
Is DSIP approved?
No. DSIP is a research peptide with no approved human use.